In October of 1904, Aaron Brown and eight of his friends founded Phi Delta Epsilon at Cornell University Medical College. During the first decade of this century there were many doors closed to Jewish medical students and physicians, doors which would not fully open until after World War II. In 1904, it was not uncommon for American medical schools to have quotas limiting admission of Jewish students, and medical fraternities. So Aaron Brown and his friends decided they would start their own fraternal organization, guided by the precepts of philanthropy, deity, and equity.

In the late 1960s, the Fraternity opened its membership to women and encouraged recruitment of medical students of all races, nationalities and religious beliefs. The past 25 years have seen the Fraternity's membership become wonderfully diverse, reflecting the diversity of the medical profession today. The addition of the premedical affiliation in 1994 rounded out the Fraternity's membership, which now spans an entire lifetime of medical education and practice.

On Sunday, December 9th, 2018, after a semester of hard work and development, South Carolina Beta received their charter. Since then, we have worked hard to develop our chapter’s membership, fraterhood, and philanthropy.